Just to make this clear (it wasn't to me when I searched the list). Mcafee support just informed me that you cannot install/run ePO console on a Vista system, and because the 4.0 interface is web based they will not be supporting it.
I should have been clearer, if you are running ePO server software 3.6.1 patch X,null and you want to put the remote console software on a Vista system this is not supported (nor will it be). ePO server 4.0 patch X uses a web interface so of course you can use a Vista client.
The ePO 3.6.1 console is an MMC snap-in. Microsoft changed MMC in Vista. That would require McAfee to create a new snap-in just for Vista. Why would they do that when 3.6.1 is scheduled to end of life 8/31/2009?