Updating IPS Rules policy.
Made some edits, click on save
Policy "acts" like it saved.
Go into policy and changes not saved.
No chages to ePO etc.
Policy was able to save a few days ago.
I'd take a look at orion.log at the time when you tried to save the policy. You can post it here, too for us to look at if you can't find anything useful (teling us the exact date and time of an attempt to save those policies again unsuccesfully).
Also you could try to check the IPS ePO extensions whether they are "running".