As of now, it doesn't look like it:
Supported platforms, environments, and operating systems for ePolicy Orchestrator Technical Articles ID: KB51569 Last Modified: 11/4/2016
as described under KB51569 Server 2016 is not official supported.
If you are installing EPO in a non supported Environment you will loose Support. It is okay for testing, but you should never do this in a productive Environment.
Download the new ePolicy Orchestrator (ePO) Support Center Extension which simplifies ePO management and provides support resources directly in the console. Learn more about ePO Support Center