In EPO 4.5 it seems that the proxy settings I must specify a proxy server for both protocols.
I need to proxy http/https, but we do NOT proxy FTP
But it doesn't seem that I can tell it to not proxy FTP (the proxy name is in the pulldown and you can't change it to NOT proxy FTP)
It looks like this option is not available, both protocols should use a proxy or none of them.
Did you try adding ftp://* to the local addresses exclusions?