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Blocking HASHES or virus from VirusTotal!!!!!

Hi Guys, Base on your expirience What is the practice to block a Virus detected by VirusTotal? Using HIPS and If I don't have HIPS what else I can do?

https://www.virustotal.com/#/file/e589c84d8e03716b0475588a2a14254219bb56c1a971c993f9ee526e8b7b0f2b/d...

Virus.PNG

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