I'm seeing the same issue in the Apache logs where [client 10.128.14.16] client denied by server configuration: E:/Program Files/McAfee/ePolicy Orchestrator/DB/ shows up many times per day. We are running ePO 4.0 P3. This issue has been going on for quite some time.
Thanks for your answer shuemr, I guess this issue occur when ePO is installed on another disc than the C:\ ... Does somebody note the same thing with the C:\ disc ? Do you notice any problem on your ePO server shuemr ? Thanks