You may have a look at Orion logs which would give you with more information. The Orion log is located in c:\program files (x86)\mcafee\epolicy orchestrator\server\logs.
Did you attempt any passwords change?
Go to https://servername:8443/core/config and validate the settings there.
Is the eventparser service running? If not, that is a failure to connect to the database.
Did you perform test.udl connection? was it working, if not see kb70929. If that fails, then you have wrong credentials, port, instance, or issues with sql going on. If that fails, there is no way epo can connect.
I highly recommend you to follow the above and see if you could resolve the issue, otherwise, you may have to talk to McAfee to get this resolved at the earliest possible time.
What Vnaidu suggested is right - those errors indicate a connection to the database failure. One thing you can check is if the sql server is using dynamic ports, did the port change on a reboot of the sql server? The orion log will show connection failures and you may have to also look to see that nothing is wrong on the sql side. Did any passwords change recently? What prompted the reboot of the server?
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