It all depends on how many exclusions you are talking about. The longer the list of exclusions, the scanner has to parse through them continuously for on access scanning to determine whether a file or folder needs to be scanned or not. I would suggest having maybe 2-4 policies, depending on the server type. Example, epo doesn't really need any, but I typically exclude the events folder and log file types. Sql server has its own low risk and file type exclusions needed, same with an Exchange server. Keeping just a basic server type policy that can apply to multiple server types, but still be scaled down for efficiency, can improve overall performance. You shouldn't need more than a few, which isn't too bad for policy maintenance. Extremely large policies are also known to cause high cpu issues with the agent when the agent is trying to apply and enforce the large policy set.
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