Your question should really be asked/posted to teh guys at Qradar, it is there product that you are using.
The dB (ePO or not) is hosted on SQL, it will be SQL and the 'product involved' that will define that. According to the URL you posted, it says:
You must enable this parameter if your connection supports SSL, even if your connection does not require it. This option requires extra configuration on your database and requires you to configure certificates on both appliances."
It reads to me that it is something you should setup, but please contatc the vendor for details and confirmation.
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