We're running version 22.214.171.124 MWG and we have "Enable GTI file reputation queries" enabled (see below). From everything I have read about GTI file reputation, I would expect to see the MWG's sending out DNS queries against the mcafee.com DNS servers with a hash of the file that is being scanned.
But I have NEVER seen a DNS lookup for anything *.avts.mcafee.com (i.e. x-0.19-a3000011.20580.16a8.b84.2fc7.200.0.divlrlqgrt8wqej5r3h1fspprv.avts.mcafee.com) from any of our Web Gateways. Does the file reputation piece work in a different way to the other products?
Here's an GTI File Reputation test file as well:
If this file goes through MWG, it should be flagged by GTI File Reputation (formerly Artemis).