When I used to have GameSpy installed, a year or two ago, McAfee also (wrongly?) Identified it as malware and insisted on removing the program and any links to it.
I think I chose to Trust it, and that prevented it from coming up in later scans. (I can't remember... it's a long while since I had GameSpy installed).
It may be worth sending the file to Avert, as suggested above, and report it as a possible false-positive. (Unless McAfee knowns something about GameSpy that we don't, but as far as I know it's a legitimate program).