Can you please let me know your True Key version, and if you are using the standalone desktop model or extension first (through the browser only)?
If you are using extension first, please let me know the browser and the TK extension version as well?
I'm having the same problem, but more frequently than only after Windows startup.
Windows 10 build: 15063.674
Chrome: Version 62.0.3202.89 (Official Build) (64-bit)
TrueKey Extension: 2.8.5711