Try running the Virtual Technician to see if it will fix things,
If not we need more information:
Your operating system and service pack
Your installed McAfee products and versions (open SecurityCenter and click 'About'.
Any other strange popups?
Can you elaborate re what is the rest of the message. is it saying it is expiring? or firewall off etc?
If it is not an expiring issue try running MVT the virtual technician and see if it finds anything
Gees peter you are fast.Message was edited by: Peacekeeper on 7/04/12 7:57:49 PM
If your computer is connected to the internet and has the correct time showing in the system clock and that's the only indication of trouble, perhaps Technical Support is best in this case as they can troubleshoot.
Linked under Useful Links at the top of the page.
Otherwise we need a lot more information as I stated in my first answer to the OP.
Please let us know what is the error message that s shown in Security center , beside the message : Your PC at risk : Is it Real time scanner disabled/Firewall Turned off etc . .