Does any part of the total protection service work with windows server 2008 R2 64 bit? I am not concerned about the browser protection.
None of the components of the McAfee Total Protection Service version 5.2 or any of the earrlier versions support the Windows 2008 R2 server. Niether 32 bit nor 64 bit.
Also see KnowledgeBase article KB60533 - Supported environments for SaaS Endpoint Protection (formerly Total Protection Service)