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Unable to open Endpoint Security or update AMCore content version

When trying to open the Mcafee endpoint security icon from the task tray. Nothing happens. Opening the application from the start menu results in error: The application was unable to start correctly (0xc0000022). Click OK to close the application. Unable to update the AMCore via EPO manager. Running Windows Server 2012 R2
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Re: Unable to open Endpoint Security or update AMCore content version

Hi @User28462607 ,

Thankyou for reaching us on community!

This could be because of missing root certificates.
I would recommend updating the root certificates as mentioned in the below article :

Once updated, you can reboot the machine and check to check if the issue still persists.

This issue would occur if you have another AV program running on the machine . Hence, you would need to uninstall the other AV and reboot the machine  to check if the issue still persists.

If the issue still persists, you can try uninstalling and reinstalling ENS on the machine. But, if the issue is wide spread and it doesn't resolve with the above recommendations, kindly open a ticket to McAfee Technical Support to  take the troubleshooting further.

I hope you find this information helpful.

-Rohit Francis 
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