what kind of performance issues?
high memory usage? high cpu? not responsive to user? please explain
how long does it last? same time every day?
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Take a look at any recommended Oracle AV exclusions as these will help you know if it is safe to exclude these processes or not. I know Oracle have some articles on required AV exclusions.
If on the list from Oracle then yes, you can add them as low risk processes. You may even need to disable scanning for low risk processes but this depends on what Oracle recommends.
You may also want to take a look at the following KB for general performance improvements:
Download the new ePolicy Orchestrator (ePO) Support Center Extension which simplifies ePO management and provides support resources directly in the console. Learn more about ePO Support Center