Did you manage to resolve your issue? - I have just come across the same problem whilst trying to Ghost my laptop.
For starters, please note - I have NOT actually done any of this on my laptop, since my Help Desk has it and is working on it - this is only the results of some of my online research.
I was not able to actually resolve my issue since my IT Help Desk took my laptop to work on. I was able to find out though - that this issue appears to be more Ghost focused than SafeBoot. When Ghost attempts to Clone a drive, it will install its very own Ghost Virtual Partition that sits in front of the regular PC boot partition. When trying to run on an encrypted drive, the Ghost Virtual Partition loads - and then cannot see the actual hard drive since it is encrypted. At that point, you get the "Missing Operating System" error. In my research, it seems like you should be able to use the FDisk commands from a command prompt (access through Windows Recovery Console or by using a Ghost Boot Disk) to remove the Ghost Virtual Partition and then re-boot and your PC "should" take you right to your SafeBoot login screen. Again, I haven't actually done this - so I cannot guarantee anything.
I would recommend you do some googling on "Removing Ghost Virtual Partition" so that you can see some of the information for yourself before attempting anything on your laptop.
I would also try some of the steps recommended by the McAfee users in their responses to me as well. They were all very helpful, but unfortunately, nothing worked on my laptop.
Some more information:
I also attempted to use Norton Ghost to image my safeboot enctyped laptop and got the same result "Missing operating system"
My help desk attempted to recover the laptop but have so far only managed to produce a different Error message: "Error loading operating system"
At this point my help desk told me that the disk was irrecoverable. Not happy with this answer I then attempted to fix the boot process myself myself using the Norton tool ghreboot.exe. This tool disables the ghost partition and tries to reboot to windows
Unfortunately this did not work, possibly because the helpdesk had already tried to restore the MBR using the Windows tools and corrupted it further.
If there was a way to force decrypt the disk and get the data off I would be more than happy.