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Email Gateway 7.5 - Connect Failed Port 25


I have email gateway 7.5 connected to Server With Hyper-V in a port.
When I try make telnet not always respond the Exchange Server, The answer is  connect failed to port 25 of the mail server.

I check the settings of Email Gateway, but is correct.
Email Gateway  Server physical conneted to Server physical of Hyper-V
In hyper-V  a VM with Exchange Server.
One Virtual Switch with port connect to Email Gateway.
anyone has any idea because the port does not respond?
this problem generates can not send email in the relay

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