I REALLY HATE IT.
Offer two versions of the software for download; the new 2010 version and the older version which seemed to have a much more simpler layout for my prefrences.
I also really hate any automated software that does not show the details of what it's doing to my data on my hard drive.
I like to see what files Quickclean is scanning, and deleting before doing so. I'm sorry I'm a Web/Graphic designer and I like to know everything that goes on in my system with any utilities that I use.