None of the leading antivirus software will protect you from this sort of malware because of the roundabout way it works, so I think you'll find that Trend wont protect you any better.
What does help is, at the first sign of unusual activity, don't click on anything, even the 'X" or Close button, because that's what activates it, shut down the PC and boot into Safe Mode and try System Restore or even the Last Known Good Configuration option often works well.
You'll find posts all over the web regarding this and many other similar nuisance malware, if you don't believe me, post the question on a good independent anti-malware forum such as BleepingComputer or similar.
Meanwhile there are tools out there designed to combat such things. A few are listed here: https://community.mcafee.com/docs/DOC-2168
Another thread on this particular pest: https://community.mcafee.com/thread/43791?start=0&tstart=0