PUPs are defined as programs that could be used for malicious purposes, but are not malicious in and of themselves. Excluding a PUP from being detected, however, is different than excluding a specific file, or folder, from being scanned by VSE’s On-Access Scanner. KB50383 (https://kc.mcafee.com/corporate/index?page=content&id=KB50383) provides information on how to make the proper exclusion.
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